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KMID : 0903520080510030223
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2008 Volume.51 No. 3 p.223 ~ p.227
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Development of Biologically Active Compounds from Edible Plant Sources XXII. Triterpenoids from the Aerial Parts of Sajabalssuk (Artemisia princeps PAMPANINI)
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Band Myun-Ho
Cho Jin-Gyeong
Song Myoung-Chong
Lee Dae-Young
Han Min-Woo
Cheng Hae-Gon
Jeong Tae-Sook
Lee Kyung-Tae
Choi Myoung-Sook
Baek Nam-In
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Abstract
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The aerial parts of Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk) was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O, successively. From the EtOAc fraction, three cycloartane-type triterpnoids and one ursanetype triterpenoid were isolated through the repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the results of physico-chemical data including NMR, MS and IR, the chemical structures of the triterpenoids were determined as wrightial (1), wrightial acetate (2), 27-norcycloart-20(21)-ene-25-al-3β-ol acetate (3) and ursolic acid (4). No report has been found for isolation of compound 3 in the literature so far, and compounds 1, 2 and 3 were the first to be isolated from Sajabalssuk (Artemisia princeps PAMPANINI, Sajabalssuk). Also, compound 1 showed Acyl-CoA:Cholesterol acyltransferase (hACAT-1) and hACAT-2 inhibitory activity with the IC50 values of 33.0 and 45.0 μg/ml, respectively. Compounds 2 and 3 inhibited hACAT-1 activity with the IC50 values of 12.0 and 16.0 μg/ml, respectively.
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KEYWORD
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Acyl-CoA:Cholesterol acyltransferase (ACAT), Artemisia princeps PAMPANINI Sajabalssuk, wrightial, wrightial acetate, 27-norcycloart-20(21)-ene-25-al-3β-ol acetate, ursolic acid
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